Introduction Nucleic acid fluorescence labeling is a critical technique in molecular biology and biochemistry, enabling the visualization and analysis of DNA and RNA molecules. Fluorescent labels provide a powerful means to investigate the behavior, location, and interaction of nucleic acids within cells and in vitro. This article reviews the key chemical methods employed in the...

Introduction The Mechanisms of protein regulation and degradation are crucial for maintaining cellular homeostasis and preventing diseases such as cancer. One of the most innovative approaches in pharmacology is the development of Proteolysis Targeting Chimeras (PROTACs), small molecules designed to promote the ubiquitin-proteasome pathway for targeted protein degradation. PROTACs have emerged...

Abstract The field of chemical compound synthesis has traditionally relied on empirical methods and expert knowledge. However, the rapid advancement of machine learning (ML) and data-driven approaches has begun to transform how chemical compounds are synthesized. This article explores the integration of these technologies into chemical synthesis, highlighting key methodologies,...