Tissues rely on extremely precise genetic information to establish their structure and function, but little work has been done to think about and ask the question of whether and how long-duration organizational changes affect genetic information. The nervous system is a fine example of the synergy between organizational structure and gene expression. Cortical development is like the...

The field of biopharmaceuticals is playing an increasingly pivotal role in medical treatment but is encountering several challenges. One pressing issue is the short half-life of many biopharmaceutical products, which leads to rapid degradation and clearance from the patient's body, necessitating frequent dosing. In this article, we explore how half-life extension strategies in drug development...

Cells, the microscopic building blocks of the human body, operate like a sophisticated symphony orchestra, finely orchestrating numerous life processes. In this diminutive yet intricate world, ribosomes function as conductors, guiding the synthesis of proteins—the essential constituents of life. However, disruptions in ribosomal function are frequently linked to cellular dysfunction,...

The term "single cell" refers to an individual cell, isolated and examined on its own. Analysis conducted specifically on individual cells is collectively referred to as single-cell sequencing analysis, while sequencing performed on these isolated cells is termed single-cell sequencing. Sequencing multiple cells or a group of cells falls outside the realm of single-cell sequencing....

Recent advancements in biomedical research have revolutionized our understanding of complex diseases. Among these innovations, spatial omics and multiplexed imaging to explore cancer biology have emerged as powerful tools for uncovering the intricate molecular landscapes within tumors. By providing spatial context and high-resolution visualization of cellular and molecular...

The global battle against the COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has tested the limits of global public health. Across the globe, scientists and researchers have displayed unwavering dedication, resulting in remarkable progress in various realms of COVID-19 research and treatment. This blog post will delve into three pivotal areas of study: the optimization of...

In recent years, the rapid advancements in precision medicine and biotechnology have ushered in unprecedented transformations in cancer treatment. Among these, exosomes, small extracellular vesicles secreted by nearly all mammalian cells, have emerged as a fascinating area of focus. Their unique biological properties and therapeutic potential have placed them at the forefront of cancer...

Plasmodium falciparum, a parasite that causes severe malaria, employs complex immune evasion mechanisms. Recent studies have focused on immunoglobulin M (IgM) to reveal how the parasite hijacks host IgM to evade immune system attacks. This article explores the mechanism of IgM polymerization, its structural characteristics in different organisms, and the detailed process of how P....

Though the COVID-19 pandemic may have somewhat faded from the forefront of public attention, its enduring impact persists. Nations worldwide have grappled with recurring waves of infection over the past three years, despite many establishing immunity barriers. However, concerns about long COVID symptoms and the potential for recurrent infections persist, posing significant challenges to...

In recent years, immune checkpoint inhibitors (ICIs) have emerged as a significant breakthrough in cancer therapy, reshaping traditional treatment paradigms. PD-1/PD-L1 pathway inhibitors have been widely used across various cancer treatments, demonstrating impressive efficacy. As PD-(L)1 inhibitor therapies continue to mature, pharmaceutical giants have turned their attention to PD-(L)1...